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1

TARGETS AND MECHANISMS OF CHEMICALLY INDUCED ANEUPLOIDY. PART 1 OF THE REPORT OF THE 2017 IWGT WORKGROUP ON ASSESSING THE RISK OF ANEUGENS FOR CARCINOGENESIS AND HEREDITARY DISEASES

Lynch, Anthony M., Eastmond, David, Elhajouji, Azeddine, Froetschl, Roland, Kirsch-Volders, Micheline, Marchetti, Francesco, Masumura, Kenichi, Pacchierotti, Francesca, Schuler, Maik, Tweats, David

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2019

Language:

english

File:

PDF, 415 KB

english, 2019

2

1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis

Bernadette Bourdin Trunz, Rafał Jędrysiak, David Tweats, Reto Brun, Marcel Kaiser, Jerzy Suwiński, Els Torreele

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 398 KB

english, 2011

3

Comparative studies on the gastric acid inhibiting drugs (loxtidine, ranitidine, cimetidine and omeprazole) using the in vivo stomach UDS assay

B. Burlinson, S. Morriss, D. Gatehouse, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1991

Language:

english

File:

PDF, 85 KB

english, 1991

4

Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests: II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test

D.J. Tweats, D. Blakey, R.H. Heflich, A. Jacobs, S.D. Jacobsen, T. Morita, T. Nohmi, M.R. O’Donovan, Y.F. Sasaki, T. Sofuni, R. Tice

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 321 KB

english, 2007

5

Genotoxicity studies of gastric acid inhibiting drugs

Burlinson, B, Morriss, S.H, Gatehouse, D.G, Tweats, D.J, Ekman, Lars, Bolcsfoldi, George, Macdonald, James, Nicols, Warren

Journal:

Year:

1990

Language:

english

File:

PDF, 324 KB

english, 1990

6

Mutagen formation after the addition of nitrite to normal human gastric juice

Gatehouse, David G., Tweats, David J.

Journal:

Year:

1982

Language:

english

File:

PDF, 181 KB

english, 1982

7

ChemInform Abstract: 1-Aryl-4-nitro-1H-imidazoles, a New Promising Series for the Treatment of Human African Trypanosomiasis.

Bernadette Bourdin Trunz, Rafal Jedrysiak, David Tweats, Reto Brun, Marcel Kaiser, Jerzy Suwinski, Els Torreele

Journal:

Year:

2011

File:

PDF, 24 KB

2011

8

Genotoxicity testing—future developments

David J. Tweats

Journal:

Year:

2006

Language:

english

File:

PDF, 69 KB

english, 2006

9

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept®, Roche): overview

Anton Pozniak, Lutz Müller, Miklos Salgo, Judith K Jones, Peter Larson, David Tweats

Journal:

AIDS Research and Therapy

Year:

2009

Language:

english

File:

PDF, 675 KB

english, 2009

10

Monitoring the marine environment for mutagens

PARRY, J. M., TWEATS, D. J., AL-MOSSAWI, M. A. J.

Journal:

Year:

1976

File:

PDF, 350 KB

1976

11

Book Reviews

Journal:

Year:

1985

Language:

english

File:

PDF, 25 KB

english, 1985

12

Mutation, cancer and transgenic models: relevance to the toxicology industry

Sullivan, Neil, Gatehouse, David, Tweats, David

Journal:

Year:

1993

Language:

english

File:

PDF, 981 KB

english, 1993

13

Plasmid pGW16, a derivative of pKM101, increases post-UV DNA synthesis, but sensitises some strains of Escherichia coli to UV

C.A. Little, D.J. Tweats, R.J. Pinney

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1991

Language:

english

File:

PDF, 760 KB

english, 1991

14

Mitotic gene conversion induced by hycanthone methanesulphonate

D.J. Tweats, D. Gatehouse

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1979

Language:

english

File:

PDF, 63 KB

english, 1979

15

Bacterial mutagenicity tests of β-lactam antibiotics

D.J.V. Paes, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1980

Language:

english

File:

PDF, 66 KB

english, 1980

16

Metaphase analysis of mouse spermatogonial cells following exposure to ranitidine

D.J. Parkes, S.A. Pascoe, D.G. Gatehouse, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1984

Language:

english

File:

PDF, 147 KB

english, 1984

17

Strategies for screening ‘high-exposure’ chemicals for genotoxicity

D.J. Tweats, D.G. Gatehouse

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1989

Language:

english

File:

PDF, 174 KB

english, 1989

18

Investigations into the induction of aneuploidy and polyploidy in cultured mammalian cells by the anti-tussive agent, noscapine

D. Gatehouse, G. Stemp, S. Pascoe, P. Wilcox, J. Oliver, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1991

Language:

english

File:

PDF, 78 KB

english, 1991

19

Toxicokinetics and hazard assessment: mutagenicity profile of a prostanoid, GR63799

D.J. Tweats, D.G. Gatehouse, B.A. Duncan, A.J. Brice

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1992

Language:

english

File:

PDF, 89 KB

english, 1992

20

Omic profiling for drug safety assessment: current trends and public–private partnerships

William M. Gallagher, David Tweats, Jochen Koenig

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 644 KB

english, 2009

21

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes

Simon R. Tew, Ying Li, Peraphan Pothacharoen, Lisa M. Tweats, Robert E. Hawkins, Timothy E. Hardingham

Journal:

Osteoarthritis and Cartilage

Year:

2005

Language:

english

File:

PDF, 594 KB

english, 2005

22

Practical issues on the application of the GHS classification criteria for germ cell mutagens

Takeshi Morita, Makoto Hayashi, Madoka Nakajima, Noriho Tanaka, David J. Tweats, Kaoru Morikawa, Toshio Sofuni

Journal:

Regulatory Toxicology and Pharmacology

Year:

2009

Language:

english

File:

PDF, 407 KB

english, 2009

23

O XIX A.1 - O XIX A.1 ICH harmonisation of genotoxicity testing for pharmaceuticals; consequences for industry and regulatory bodies

Lutz Müller, David Tweats, Toshio Sofuni, Leonard Schechtman, Gregory Probst, Hiroyasu Shimada

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 97 KB

english, 1997

24

Impact of ICH guidelines on genotoxicity testing

Journal:

Pharmaceutical Science & Technology Today

Year:

1998

Language:

english

File:

PDF, 196 KB

english, 1998

25

Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride

Gatehouse, D.G., Stemp, G., Pascoe, S., Wilcox, P., Hawker, J., Tweats, D.J.

Journal:

Year:

1991

Language:

english

File:

PDF, 508 KB

english, 1991

26

Testing strategies in mutagenicity and genetic toxicology: An appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes

D.J. Kirkland, L. Henderson, D. Marzin, L. Müller, J.M. Parry, G. Speit, D.J. Tweats, G.M. Williams

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2005

Language:

english

File:

PDF, 227 KB

english, 2005

27

Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests: I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards

D.J. Tweats, D. Blakey, R.H. Heflich, A. Jacobs, S.D. Jacobsen, T. Morita, T. Nohmi, M.R. O’Donovan, Y.F. Sasaki, T. Sofuni, R. Tice

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 533 KB

english, 2007

28

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

David Kirkland, Stefan Pfuhler, David Tweats, Marilyn Aardema, Raffaella Corvi, Firouz Darroudi, Azeddine Elhajouji, Hansruedi Glatt, Paul Hastwell, Makoto Hayashi, Peter Kasper, Stephan Kirchner, Ant

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 2.21 MB

english, 2007

29

Future approaches for genotoxicity testing of drugs and impurities

Journal:

Toxicology Letters

Year:

2010

Language:

english

File:

PDF, 50 KB

english, 2010

30

ICH-Harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact

Lutz Müller, Yasumoto Kikuchi, Gregory Probst, Leonard Schechtman, Hiroyasu Shimada, Toshio Sofuni, David Tweats

Journal:

Mutation Research/Reviews in Mutation Research

Year:

1999

Language:

english

File:

PDF, 209 KB

english, 1999

31

Omics and the detection of potential carcinogenicity in vitro: Challenges in the light of the EU Cosmetic Directive

David Tweats, Tim Gant, Paul Carmichael

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 64 KB

english, 2008

32

The Viracept-EMS case: Impact and outlook

Vernon E. Walker, Daniel A. Casciano, David J. Tweats

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 252 KB

english, 2009

33

Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive

Tweats, D.J., Scott, A.D., Westmoreland, C., Carmichael, P.L.

Journal:

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

34

Proposal to update and remove the carcinogenic classification assigned to iodomethane

Bowen, Damian, Rose, Patrick, Leconte, Florence, Tweats, David

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 63 KB

english, 2014

35

Does bleeding induce micronuclei via erythropoietin in Han-Wistar rats?

Molloy, Jenny, Foster, John R., Thomas, Helen, O'Donovan, Mike R., Tweats, David, Doherty, Ann T.

Journal:

Toxicology Research

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

36

Cell-based assays

Fielder, Robin J., Wood, G. M., Benford, Diane J., Robertson, W. R., Lambert, A., Tweats, D. J.

Journal:

Analytical Proceedings

Year:

1992

Language:

english

File:

PDF, 2.02 MB

english, 1992

37

What Relapsed/Refractory Cll/Mcl Treatment Outcomes Do German Patients And Physicians Find Most Important? Results from Qualitative Interviews

Gaudig, M., Ireland, S., Musingarimi, P., Jackson, C., Tweats, E., Eriksson, J.A., Landfeldt, E.

Journal:

Value in Health

Year:

2014

Language:

english

File:

PDF, 66 KB

english, 2014

38

An analysis of results from 305 compounds tested with the yeast RAD54-GFP genotoxicity assay (GreenScreen GC) including relative predictivity of regulatory tests and rodent carcinogenesis and performance with autofluorescent and coloured compounds

Knight, A. W., Billinton, N., Cahill, P. A., Scott, A., Harvey, J. S., Roberts, K. J., Tweats, D. J., Keenan, P. O., Walmsley, R. M.

Journal:

Year:

2007

Language:

english

File:

PDF, 119 KB

english, 2007

39

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

Torreele, Els, Bourdin Trunz, Bernadette, Tweats, David, Kaiser, Marcel, Brun, Reto, Mazué, Guy, Bray, Michael A., Pécoul, Bernard, Boelaert, Marleen

Journal:

PLoS Neglected Tropical Diseases

Year:

2010

Language:

english

File:

PDF, 316 KB

english, 2010

40

Uptake of tritiated thymidine by cells of the rat gastric mucosa after exposure to loxtidine or omeprazole

Burlinson, B., Morriss, S., Gatehouse, D. G., Tweats, D. J., Jackson, M. R. M

Journal:

Year:

1991

Language:

english

File:

PDF, 1.57 MB

english, 1991

41

The preclinical toxicological evaluation of sumatriptan

Owen, K., Hartley, K., Tucker, M., Parkinson, M., Tweats, D., Jackson, M.

Journal:

Human & Experimental Toxicology

Year:

1995

Language:

english

File:

PDF, 1.36 MB

english, 1995

42

R Factor-mediated Resistance to Ultraviolet Light in Strains of Escherichia coli Deficient in Known Repair Functions

Tweats, D. J., Thompson, M. J., Pinney, R. J., Smith, J. T.

Journal:

Journal of General Microbiology

Year:

1976

Language:

english

File:

PDF, 754 KB

english, 1976

43

A differential killing assay for mutagens and carcinogens based on an improved repair-deficient strain of Escherichia coli

Tweats, D.J., Green, Michael H.L., Muriel, W.J.

Journal:

Year:

1981

Language:

english

File:

PDF, 1.42 MB

english, 1981

44

The predictive value of batteries of short‐term tests for carcinogens

Journal:

Food Additives & Contaminants

Year:

1984

Language:

english

File:

PDF, 637 KB

english, 1984

45

Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness)

Tweats, D., Bourdin Trunz, B., Torreele, E.

Journal:

Year:

2012

Language:

english

File:

PDF, 367 KB

english, 2012

46

Joint EFPIA/CHMP SWP workshop: the Emerging Use of Omic Technologies for Regulatory Non-Clinical Safety Testing

Kasper, Peter, Oliver, Gerry, Lima, Beatriz Silva, Singer, Thomas, Tweats, David

Journal:

Pharmacogenomics

Year:

2005

Language:

english

File:

PDF, 53 KB

english, 2005

47

Patient, physician, and general population preferences for treatment characteristics in relapsed or refractory chronic lymphocytic leukemia: A conjoint analysis

Landfeldt, Erik, Eriksson, Jennifer, Ireland, Steve, Musingarimi, Patience, Jackson, Claire, Tweats, Emma, Gaudig, Maren

Journal:

Leukemia Research

Year:

2016

Language:

english

File:

PDF, 754 KB

english, 2016

48

Relevance of plasmid pKM101-mediated mutagenicity in bacteria to genotoxicity in mammalian cells

Little, C.A., Tweats, D.J., Pinney, R.J.

Journal:

Year:

1989

Language:

english

File:

PDF, 508 KB

english, 1989

49

Further debate of testing strategies

Tweats, David J., Gatehouse, David G.

Journal:

Year:

1988

Language:

english

File:

PDF, 665 KB

english, 1988

50

Letter to the Editor

Gatehouse, D.G., Tweats, D.J.

Journal:

Year:

1986

Language:

english

File:

PDF, 228 KB

english, 1986

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